rs879253942
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Liver metastases (n = 93) along with primary tumors (n = 48) were analyzed for K-Ras mutations (codons 12 and 13), p53 mutations (exons 4-9), p53 polymorphism (codon 72), thymidylate synthase (TS) polymorphism (28-bp repeats including G>C mutation), methylenetetrahydrofolate reductase polymorphism (677C>T, 1298A>C), thymidylate synthase (TS) activity, dihydropyrimidine dehydrogenase activity, folylpolyglutamate synthase activity, and p53 protein expression.
|
18676755 |
2008 |
rs878854066
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The p53 R72P genotype was identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method in 78 consecutive colorectal cancer patients with liver metastases and 214 age- and sex-matched cases with nonmetastatic colorectal cancer.
|
18988302 |
2008 |
rs876660572
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The ERBB4 (T272A) mutation observed in P1-4, however, disappeared in H1.
|
25623536 |
2015 |
rs773197447
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The SMAD4 (N129K and G508D) mutations observed in P2-1, however, were nor detected in H2.
|
25623536 |
2015 |
rs765433422
|
|
|
0.010 |
GeneticVariation |
BEFREE |
KRAS c.34G>A mutation was detected in primary tumor and liver metastasis, which additionally revealed 2 rare PI3KCA mutations (c.1633G>C and c.1645G>C).
|
29409955 |
2018 |
rs75873440
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, RET p.G533C-expressing cells were able to induce liver metastasis in nude mice.
|
21834681 |
2011 |
rs758204762
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Whole-exome sequencing of the primary HER2-negative breast cancer and its HER2-negative synchronous liver metastasis from a 46-year-old female revealed the presence of an activating and clonal HER3 G284R mutation.
|
25953157 |
2015 |
rs756090401
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The SMAD4 (N129K and G508D) mutations observed in P2-1, however, were nor detected in H2.
|
25623536 |
2015 |
rs7553007
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Both the CRP SNP rs7553007 and KRAS/BRAF mutations were independent prognostic factors for CRC patients with synchronous liver metastasis.
|
23755178 |
2014 |
rs752742313
|
|
|
0.010 |
GeneticVariation |
BEFREE |
As a proof of the concept, we present the case of a metastatic patient with a PIK3CA wild-type primary tumor in which the PIK3CA E545K mutation was identified in both the circulating-free DNA obtained from a peripheral blood sample and in the formalin-fixed, paraffin-embedded liver metastasis.
|
26001593 |
2015 |
rs4872077
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A novel germline truncating mutation of DR5/TNFRSF10B was identified, and DR4/TNFRSF10A SNP rs4872077 was associated with the development of liver metastases (p = 0.02).
|
18590575 |
2008 |
rs397517096
|
|
|
0.010 |
GeneticVariation |
BEFREE |
L747P (2239-2240 TT>CC) in exon 19 is a rare EGFR mutation that appears to lead to gefitinib resistance and might accelerate liver metastases.
|
26339441 |
2015 |
rs397507444
|
|
|
0.010 |
GeneticVariation |
BEFREE |
677C>T and 1298A>C genotypes were determined simultaneously by melting curve analyses on liver metastases.
|
15608557 |
2004 |
rs2910164
|
|
|
0.010 |
GeneticVariation |
BEFREE |
miR-146a Polymorphism (rs2910164) Predicts Colorectal Cancer Patients' Susceptibility to Liver Metastasis.
|
27824903 |
2016 |
rs1452020002
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The SMAD4 (N129K and G508D) mutations observed in P2-1, however, were nor detected in H2.
|
25623536 |
2015 |
rs1345316856
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Cell lines stably expressing mutant PRPK (S250A), knockdown TOPK, knockdown PRPK or knockdown of both TOPK and PRPK significantly inhibited liver metastasis of human HCT116 colon cancer cells in a xenograft mouse model.
|
28412249 |
2017 |
rs121913530
|
|
|
0.010 |
GeneticVariation |
BEFREE |
KRAS c.34G>A mutation was detected in primary tumor and liver metastasis, which additionally revealed 2 rare PI3KCA mutations (c.1633G>C and c.1645G>C).
|
29409955 |
2018 |
rs121913377
|
|
|
0.010 |
GeneticVariation |
BEFREE |
BRAF V600E and SRC mutations were mutually exclusive, and SRC mutation was significantly associated with left-sided tumor and liver metastasis compared to BRAF V600E mutation (P = 0.016 and P = 0.025, respectively).
|
30792536 |
2019 |
rs121913250
|
|
|
0.010 |
GeneticVariation |
BEFREE |
KRAS c.34G>A mutation was detected in primary tumor and liver metastasis, which additionally revealed 2 rare PI3KCA mutations (c.1633G>C and c.1645G>C).
|
29409955 |
2018 |
rs121913247
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Finally, a <i>MET</i>ex14 del mutation-positive NSCLC patient who responded to crizotinib but later relapsed, demonstrated a mixed response to glesatinib including reduction in size of a <i>MET</i> Y1230H mutation-positive liver metastasis and concurrent loss of detection of this mutation in plasma DNA.<b>Conclusions:</b> Together, these data demonstrate that glesatinib exhibits a distinct mechanism of target inhibition and can overcome resistance to type I MET inhibitors.<i></i>.
|
28765324 |
2017 |
rs1217691063
|
|
|
0.010 |
GeneticVariation |
BEFREE |
677C>T and 1298A>C genotypes were determined simultaneously by melting curve analyses on liver metastases.
|
15608557 |
2004 |
rs121434569
|
|
|
0.020 |
GeneticVariation |
BEFREE |
First-line gefitinib, longer EGFR TKI treatment duration, male, initial liver metastasis and uncommon EGFR mutations may be independent factors for secondary EGFR T790M mutation.
|
30485437 |
2019 |
rs121434569
|
|
|
0.020 |
GeneticVariation |
BEFREE |
After her death, an autopsy revealed SCLC transformation and EGFR T790M secondary mutation (T790M) as mutually exclusive resistance mechanisms occurring differently in different metastases; two liver metastases (SCLC versus AC with T790M) and two lymph node metastases (SCLC versus AC with T790M) were analyzed to compare the expression status of immune markers by immunohistochemistry and by an immune oncology gene expression panel.
|
28193529 |
2017 |
rs121434568
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, patients with EGFR 19del and LM showed marginally significantly shorter OS (P = .0531) and patients with EGFR L858R and LM had OS similar to that of patients without LM (P = .1883).
|
28549835 |
2017 |
rs113488022
|
|
|
0.010 |
GeneticVariation |
BEFREE |
BRAF V600E and SRC mutations were mutually exclusive, and SRC mutation was significantly associated with left-sided tumor and liver metastasis compared to BRAF V600E mutation (P = 0.016 and P = 0.025, respectively).
|
30792536 |
2019 |